There are direct flights from all the major European airports into Florence and there are direct flights from major U.S. airports to the major European airports.
So try one of these combinations, fly directly to Florence. You can skip Rome! That will put you in the heart of Tuscany normally with just one stop.
One precaution is that both flights need to be on a single ticket, otherwise, if the first flight is delayed you may miss the second flight and lose it’s value. Also, with a single ticket your bags can be checked all the way through to your destination. Several major airlines have connections like the following:
U.S.
Atlanta Boston Chicago Dallas Los Angeles Miami New York San Francisco Seattle
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Europe 1-stop
Amsterdam Frankfurt London Paris
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Tuscany
Florence, Italy
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